Curriculum Modeling the Dependence among Targets with Multi-task Learning for Financial Marketing

Multi-task learning for various real-world applications usually involves tasks with logical sequential dependence. For example, in online marketing, the cascade behavior pattern of $impression \rightarrow click \rightarrow conversion$ is usually modeled as multiple tasks in a multi-task manner, where the sequential dependence between tasks is simply connected with an explicitly defined function or implicitly transferred information in current works. These methods alleviate the data sparsity problem for long-path sequential tasks as the positive feedback becomes sparser along with the task sequence. However, the error accumulation and negative transfer will be a severe problem for downstream tasks. Especially, at the beginning stage of training, the optimization for parameters of former tasks is not converged yet, and thus the information transferred to downstream tasks is negative. In this paper, we propose a prior information merged model (\textbf{PIMM}), which explicitly models the logical dependence among tasks with a novel prior information merged (\textbf{PIM}) module for multiple sequential dependence task learning in a curriculum manner. Specifically, the PIM randomly selects the true label information or the prior task prediction with a soft sampling strategy to transfer to the downstream task during the training. Following an easy-to-difficult curriculum paradigm, we dynamically adjust the sampling probability to ensure that the downstream task will get the effective information along with the training. The offline experimental results on both public and product datasets verify that PIMM outperforms state-of-the-art baselines. Moreover, we deploy the PIMM in a large-scale FinTech platform, and the online experiments also demonstrate the effectiveness of PIMM

(μ-6-Oxido-4-oxo-1,2-dihydro­pyrimidine-5-carboxyl­ato-κ4 O 5,O 6:O 2,N 3)bis­[aquabis­(4-oxido-2-oxo-1,2-dihydro­pyrimidin-3-ium-5-carboxyl­ato-κ2 O 4,O 5)­(1,10-phenanthroline-κ2 N,N′)neodymium(III)] hexa­hydrate

The water-coordinated neodymium(III) atom in the centrosymmetric title compound, [Nd2(C5H2N2O4)(C5H3N2O4)4(C12H8N2)2(H2O)2]·6H2O is chelated by a 1,10-phenanthroline heterocycle and two 2,4-dihydroxy­pyrimidine-5-carboxyl­ate dianions. Two tris-chelated water-coordinated units are bridged by a 2,4-dihydroxy­pyrimidine-5-carboxyl­ate dianion, which is disordered about a center of inversion. The metal center has a monocapped square-anti­prismatic coordination

Synergistic effect of phosphodiesterase 4 inhibitor and serum on migration of endotoxin-stimulated macrophages.

Macrophage migration is an essential step in host defense against infection and wound healing. Elevation of cAMP by inhibiting phosphodiesterase 4 (PDE4), enzymes that specifically degrade cAMP, is known to suppress various inflammatory responses in activated macrophages, but the role of PDE4 in macrophage migration is poorly understood. Here we show that the migration of Raw 264.7 macrophages stimulated with LPS was markedly and dose-dependently induced by the PDE4 inhibitor rolipram as assessed by scratch wound healing assay. Additionally, this response required the involvement of serum in the culture medium as serum starvation abrogated the effect. Further analysis revealed that rolipram and serum exhibited synergistic effect on the migration, and the influence of serum was independent of PDE4 mRNA expression in LPS-stimulated macrophages. Moreover, the enhanced migration by rolipram was mediated by activating cAMP/exchange proteins directly activated by cAMP (Epac) signaling, presumably via interaction with LPS/TLR4 signaling with the participation of unknown serum components. These results suggest that PDE4 inhibitors, together with serum components, may serve as positive regulators of macrophage recruitment for more efficient pathogen clearance and wound repair

Addressless: A New Internet Server Model to Prevent Network Scanning

Eliminating unnecessary exposure is a principle of server security. The huge IPv6 address space enhances security by making scanning infeasible, however, with recent advances of IPv6 scanning technologies, network scanning is again threatening server security. In this paper, we propose a new model named addressless server, which separates the server into an entrance module and a main service module, and assigns an IPv6 prefix instead of an IPv6 address to the main service module. The entrance module generates a legitimate IPv6 address under this prefix by encrypting the client address, so that the client can access the main server on a destination address that is different in each connection. In this way, the model provides isolation to the main server, prevents network scanning, and minimizes exposure. Moreover it provides a novel framework that supports flexible load balancing, high-availability, and other desirable features. The model is simple and does not require any modification to the client or the network. We implement a prototype and experiments show that our model can prevent the main server from being scanned at a slight performance cost

1-Cyano-N-(2,4,5-trichloro­phen­yl)cyclo­propane-1-carboxamide

In the title compound, C11H7Cl3N3O, the dihedral angle between the benzene and cyclo­propane rings is 85.8 (2)°. In the crystal, mol­ecules are linked by C—H⋯O inter­actions, generating C(5) chains propagating in the a-axis direction

Efficient generation of relativistic near-single-cycle mid-infrared pulses in plasmas

Ultrashort intense optical pulses in the mid-infrared (mid-IR) region are very important for broad applications ranging from super-resolution spectroscopy to attosecond X-ray pulse generation and particle acceleration. However, currently, it is still difficult to produce few-cycle mid-IR pulses of relativistic intensities using standard optical techniques. Here, we propose and numerically demonstrate a novel scheme to produce these mid-IR pulses based on laser-driven plasma optical modulation. In this scheme, a plasma wake is first excited by an intense drive laser pulse in an underdense plasma, and a signal laser pulse initially at the same wavelength (1 micron) as that of the drive laser is subsequently injected into the plasma wake. The signal pulse is converted to a relativistic multi-millijoule near-single-cycle mid-IR pulse with a central wavelength of ~5 microns via frequency-downshifting, where the energy conversion efficiency is as high as approximately 30% when the drive and signal laser pulses are both at a few tens of millijoules at the beginning. Our scheme can be realized with terawatt-class kHz laser systems, which may bring new opportunities in high-field physics and ultrafast science

(6-Oxido-2-oxo-1,2-dihydropyrimidine-5-carboxylato-κ2 O 5,O 6)(4-oxido-2-oxo-1,2-dihydropyrimidin-3-ium-5-carboxyl­ato-κ2 O 4,O 5)bis(1,10-phenanthroline-κ2 N,N′)erbium(III) dihydrate

The erbium(III) atom in the title compound, [Er(C5H2N2O4)(C5H3N2O4)(C12H8N2)2]·2H2O, is located on a twofold rotation axis and chelated by two 1,10-phenanthroline heterocycles as well as by a 2,4-dihydroxy­pyrimidine-5-car­box­yl­ate monoanion and a 2,4-dihydroxy­pyrimidine-5-car­box­yl­ate dianion in a square-anti­prismatic coordination geometry